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However, these results were insufficient to confirm the stability of ligandprotein binding and subsequent enzyme activation because docking deals with proteins as rigid molecules and ignore time evolution in ligandprotein interaction

It has long been understood that PCOS, as a disorder, is much more than just pathological ovarian cysts and in fact encompasses diverse endocrine and metabolic features and that these features contribute to delayed definitive diagnosis and a resulting fragmentation in delivery of care

in the future, a major focus will be on defining disease-specific mechanisms of protein misfolding that constitute the basis for novel therapies

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