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doi: 10.1093/bmb/ldg032

Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

(PubMed) Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J

Some patients experience headache, others may feel nauseated
