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2011 Jul;151(3):366-9

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doi: 10.1101/CSHPERSPECT.A025247 27 Bustamante-TorresM.Arcentales-VeraB.Estrella-NuezJ.Ynez-VegaH.BucioE

By age 40, natural copper peptide stores are reduced by more than half, which dramatically impacts the skins ability to repair itself, produce collagen, and maintain firmness and elasticity
