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YangYWengWPengJHongLYangLToiyamaYet al Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-B, and Up-regulating expression of MicroRNA-21

Upon oral administration, gastrointestinal epithelium acts as a physical and biochemical barrier for absorption of proteins resulting in low bioavailability (typically less than 12%)
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