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Moreover, the unclear regulatory relationship between the H3K14la/PMCA2 axis and microglial pyroptosis further undermines the theoretical foundation for targeting the integrated neurovascularimmune cell death network

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It activates the Nrf2 pathway, directing glutamine catabolism toward GSH production and reducing glutamates role in biosynthesis

Abstract Folate receptor alpha (FR) is a high-affinity transporter responsible for delivering folate (vitamin B9) into the central nervous system (CNS), supporting the synthesis of nucleic acids, amino acids, lipids, and signaling molecules through one-carbon transfer pathways