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doi: 10.1007/s10815-019-01555-1 259 MaieseK

Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model

Application of MALDIMSI across diverse malignanciesincluding colorectal, lung, breast, liver, and brain tumorshas uncovered spatially organized metabolic gradients associated with hypoxia, immune infiltration, stromal composition, and therapeutic response, thereby providing mechanistic insights into regional immune suppression and functional divergence of immune cells within the TME (98, 99)