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Description
The presence of defects can act as a discontinuity boundary that generates a disordered interdomain region that can stop the propagation and limit the size of the domain itself and hence the final level of amplification that can be reached

This allows oral megadoses (e.g., 1,000 g or more daily) to raise serum B levels even in individuals with pernicious anemia or low stomach acid

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Cancer Discov 3:11901205 Chen Y, Terajima M, Yang Y, Sun L, Ahn Y-H, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM (2015) Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
