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Abstract Within the consistent daily rhythm of human life, intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces, leading to significant morphological changes (in terms of volume, area, and height) as well as biomechanical alterations, including an increase in disc stiffness and a decrease in intradiscal pressure

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In addition to this, the brain receives information from the gut through a continuous flow of microbial, endocrine, metabolic and immune factors