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Cold sores are also more likely to cause additional symptoms beyond the lesions, including: fever fatigue malaise swollen lymph nodes in the neck Both types of lesions can cause a burning or tingling sensation on the skin that may start a few days before the lesions appear

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Key molecules, such as GPX4 and SLC7A11, are central to ferroptosis regulation ( Figure 1 )

Another strategy relies on inhibition of the glycine transporter (sarcosine, bitopertin) or of D-amino acid oxidase (DAAO), the enzyme that metabolizes D-serine (sodium benzoate)