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Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria

An improved version of ProSavin , OXB-102 (NCT03720418, Table 1), is under investigation in a two-phase trial including an open-label, dose-finding phase, in which patients will receive one of three escalating doses, and a randomized, double-blind phase in which patients will be randomized to either an active group receiving the selected dose from phase 1, or a control group