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While PDE5 is almost undetectable in heathy cardiomyocytes, localized at Z-disks, enzyme expression is significantly upregulated and diffusely distributed in pathologic conditions, such as congestive heart failure, right ventricular hypertrophy, overload hypertrophy, ischemic cardiomyopathy (5558)

The long-term implications of sustained, high-intensity c-Met activation are not fully characterized

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