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Assembly of the middosome induces association and activation of the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) which can trigger several different pathways (Pereira and Gazzinelli, 2023)

Our professional observation is that while the logic of local injections is appealing, its practical execution in a research setting introduces numerous variables that can be difficult to control

Supraphysiological dosing does not necessarily translate into better results and may increase risk

[DOI] [PubMed] [Google Scholar] 184.Geng Y., Liu Z., Hu R., Huang Y., Li F., Ma W., Wu X., Dong H., Song K., Xu X., et al