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Current Diagnosis & Treatment in Orthopedics
Second, modulating key lipid-metabolizing enzymes, especially ACSL4, reduces PUFA incorporation into membrane phospholipids, lowering the substrate pool for lipid peroxidation and decreasing ferroptosis susceptibility
It is also important to rotate the injection site each week to prevent irritation or tissue damage
Therefore, a high level of cellular GSH may still partly feedback-inhibit even if the GSH1 is under the control of a constitutive promoter pTEF1 , i.e., by inhibiting Gsh1 enzyme activity
