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References 1 MitrutPDoceaAOKamalAMMitrutRCalinaDGofitaEet al

25 In addition, lipofuscin accumulation enhances caspase-3 activity and promotes lysosomal membrane disruption, which is linked to the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome and induction of necroptosis

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