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They are intended to distinguish mandatory, guideline-level actions (e.g., dose reduction or drug avoidance) from optional, information-modifying markers, rather than to reproduce an official CPIC, grading system

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Localised iron overload has been associated with several neurodegenerative diseases (i.e., Alzheimers disease and Parkinsons disease), based on measurements of elevated brain iron, demonstrated through magnetic resonance imaging (MRI) imaging [23-25] , ferritin in cerebrospinal fluid (CSF) [26,27] , and postmortem analyses [28-30]

This indicates that both proteins apparently act along a pathway that directs Cu from endosomes to toxicity targets in the cytoplasm and in mitochondria 4,5,31,48
