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In some cases, phase 1 research can involve patients with the condition under investigation
doi: 10.1016/j.ecoenv.2024.115960
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The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate
