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This redox state change of GPX4 is associated with a change between the reduced form GSH or the oxidized GSH disulfide form/GSSH, which ultimately converts toxic PLOOH to chemically inert lipid alcohols/PLOH [85]

J Neurosci 18:62416253 Ballatori N, Hammond CL, Cunningham JB, Krance SM, Marchan R (2005) Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins

The clinical picture in -thalassemia trait is identical to that described for -thalassemia minor, that is, small red cells (microcytosis), minimal or no anemia, and no abnormal physical signs

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