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doi: 10.1007/s40279-014-0276-5 [DOI] [PubMed] [Google Scholar] [112].Knez WL, Jenkins DG, Coombes JS

Once opened, the vial should be resealed properly and returned to cold storage

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In preclinical models of obesity, hypoxia-driven endothelial dysfunction promotes systemic insulin resistance through chronic inflammation 56,57 , excessive macrophage infiltration 58 , immune cell polarization toward a proinflammatory phenotype 59 , and ECM remodeling 60 , ultimately impairing adipocyte function and exacerbating metabolic dysregulation