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Currently, the worlds first dual-payload ADC to enter clinical trials is KH815 (an anti-TROP2 ADC) developed by Chinas Kanghong Pharma (NCT06885645): this drug links two types of toxins, a topoisomerase I inhibitor and an RNA polymerase II inhibitor, to enhance antitumor efficacy by inducing DNA double-strand breaks on one hand and inhibiting RNA synthesis on the other

Older machines, no wash water installed Yes can be mounted after, sled needed to be changed and tank need to be mounted Wash water tank, +/- 100L Purpose of wash water, to clean gauges As REAL ice creates fewer gauges, less wash water will be needed We recommend using wash water Wash water needs to have some temperature, approx

Dilution of Concentrated Drugs: In clinical practice, medications may be supplied in concentrated forms that necessitate dilution to achieve the desired concentration for patient administration

doi: 10.1016/j.ymgme.2004.04.005