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The liraglutide SmPC, for example, advises considering discontinuation if a clinically relevant sustained increase in resting heart rate is observed

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This 15-amino-acid peptide, derived from a protective compound naturally found in gastric juice, has been the subject of hundreds of preclinical studies examining its potential effects on tissue repair, gut health, and neuroprotection

Furthermore, IOP-lowering drugs are unsuccessful at treating glaucoma in 30% of patients, revealing that some cases of glaucoma may be IOP-independent (Doucette et al., 2015)