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A randomized, double-blind trial published in the Journal of Wound Care examined 82 patients with diabetic foot ulcers treated with either GHK-Cu-containing hydrogel dressing (1% concentration) or placebo gel over 12 weeks

But for some researchers, this novel side effect may influence the risk-benefit calculation when choosing between the two compounds

Tris 20 mM, NaCl 150 mM, Tween 20 detergent 0.1% (w/v)) for 1 h at room temperature, followed by primary antibody incubation in TBST overnight at 4 C

In response to stressful conditions, it trimerizes, translocates into the nucleus, binds to the heat shock element of target genes and activates the transcription of HSPs, including HSP70/90 (Noble and Shen, 2012)