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Studies, including Le Blanc et al

Patients were instructed to use high dose vitamin B12 nasal drops (5,000 mcg one nasal drop in each nostril, twice per week)

The proportion of Ngn1 + /Tbr2 + as well as Tis21 GFP + /Tbr2 + BPs in the VZ was similar in control and Gpr124 KO BPs (Appendix Fig S2M and N), suggesting that cell fate of the BPs was not altered after inhibition of brain angiogenesis and that the regulation of the switch to neurogenesis by angiogenesis occurred most likely at the level of RGs rather than BPs

Patients with PSC may also experience complications involving other digestive organs, such as liver cancer (cholangiocarcinoma) and pancreatitis, highlighting the importance of comprehensive diagnostic assessments