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Description
Distribution Both trimethoprim and sulfamethoxazole exist in the blood as unbound, protein-bound and metabolized forms
After significant industry pushback, legislative action, and public comment, NAC products returned to the market and remain widely available
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N-demethylation of hydrocodone to form norhydrocodone via CYP3A4 while O-demethylation of hydrocodone to hydromorphone is predominantly catalyzed by CYP2D6 and to a lesser extent by an unknown low affinity CYP enzyme
