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FT-IR spectra were performed utilizing KBr pellets on a Perkin Elmer (Precisely Spectrum One) in the range of 4004000 cm 1

An ideal antioxidant should be readily absorbed, remove RONs and, eventually, chelate metals at physiologically suitable concentrations [7,8]

Among several AKR inhibitors tested against AKR1B15, only JF0064 significantly inhibited AKR1B15 while potent inhibitors of AKR1B1 and AKR1B10 such as tolrestat, epalrestat, sulindac, and sorbinil failed to inhibit AKR1B15

[59] used 3 IH neuron models (hypoxia duration: 2, 5, 10 min) to determine the appropriate hypoxia time to study autophagy, their results indicated that the hypoxia phase (1.5%O 2 ) for 5 min and reoxygenation phase (21%O 2 ) for 10 min led to significant difference on the markers of apoptosis and autophagy