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Nucleic Acids Res 45 , 60236036 (2017)

ChaC1 overexpression depletes GSH, initiating and executing ferroptosis

Whereas, the AutoDock 4.2 results indicated that the targets CREBBP, NTRK2, MAP2K1, PDE2A, MAP4K4, PRKAA1, NTRK3, PRKAA2, CDK1, RELA, SOD2, UBB, IGF1R, ADORA1, NTRK1, and HIF1A exhibited binding energy between 1.77 and 9.24 kcal/mol

Eight key components in Astragalus membranaceus Bunge, including hederagenin, quercetin, calycosin, formononetin, jaranol, isorhamnetin, astragaloside III, and 9,10-dimethoxypterocarpan-3-O--D-glucoside, are involved in lipid metabolism, programmed cell death, fatty acid metabolism, which produce the ability to regulate the body's immune function, strengthen the heart, protect CM, improve substance metabolism (164), AS-IV is a cyclic aromatic triterpene glycoside compound, which is one of the main active components of Astragalus membranaceus Bunge and has good antioxidant activity (165), and can alleviate cardiotoxicity by anti-OS and improving myocardial energy metabolism