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Tofacitinib is a first-generation JAK inhibitor that mainly targets JAK3, JAK2, and JAK1 and blocks the JAK signal transduction pathway by binding to the ATP-binding site in the JAK protein, thereby relieving psoriatic arthritis

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According to the findings, copper chelators and copper transporter protein inhibitors significantly reduced neuronal cell mortality, ameliorated neurocognitive deficits, and averted A deposition [83, 84]