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With over 14 years of clinical trial data and 7 years of real-world use, semaglutide represents one of the more thoroughly studied medications in its class, though it's important to recognize that very long-term data (beyond 57 years of continuous use) remains limited

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Within the acidified endosomes, TLR9 directly binds these CpG-rich mtDNA fragments, initiating an innate immune response