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Methylcobalamin is best, unless you suffer from Lebers hereditary optic neuropathy (1 in 30,000 to 50,000 people), where hydroxy B12 is safer

At Flow Wellness, patients receive ongoing provider support, body composition monitoring, and treatment plans built around their goals to help maximize results while minimizing side effects during dose escalation

For a full breakdown of the regulatory landscape, see BPC-157 and the FDA's Category 2 classification

Medication Interactions Certain medications reduce the absorption of methylcobalamin, cyanocobalamin, and other B12 supplements, including: Proton pump inhibitors (omeprazole, esomeprazole, and lansoprazole) H2-receptor antagonists (cimetidine, famotidine, and ranitidine) Metformin Colchicine Cholestyramine Certain antibiotics (neomycin and chloramphenicol) If you use these or other medications, talk with a healthcare provider about ways to maintain healthy levels of B12.