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In comparison, direct NSP inhibitors have rapid onset but may require more frequent dosing and have limited inhibitory effects on high-concentration NSPs at inflammatory sites

As such, strong or moderate CYP3A4 inducers may increase metabolite (M1) exposure and risk of QTc interval prolongation

Topical evidence for skin improvement is strong at the mechanism level (collagen, elastin, GAG synthesis upregulation in fibroblasts) and moderate at the human cosmetic-trial level (Leyden 2002 conference abstract

Only a small percentage of a standard oral dose is absorbed through this active pathway, and that number drops further when digestion is impaired
