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10.4049/jimmunol.0901473 J

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Mitochondria are selectively targeted for autophagic degradation, and once they are recruited to the mitochondrial surface by the autophagy machinery, autophagosomes selectively capture and remove damaged mitochondria
Topiramate The mechanism of action of topiramate in neuropathic pain is thought to be by sodium channel blockade, and rationale for inclusion is similar to that of amitriptyline