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Considering the established involvement of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and transforming growth factor-beta1 (TGF-1) in RA, this research aimed to assess efficacy and safety of L-carnitine as an adjunct therapy targeting these pathways

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Further research in humans is thus needed to further assess the effects of ghrelin antagonism on body weight especially under conditions of obesity.
