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We show, using high-resolution cryo-EM, the binding of a benzene sulphonamide compound with a PV serotype 2 VLP, consistent with antiviral activity through over-stabilizing the interprotomer pocket, preventing the capsid rearrangements necessary for viral infection

Ring- or trophozoite-infected and non-infected normal or GR-deficient RBCs were fluorescent-labeled for the phagocytosis assay during 10 min incubation at room temperature with 0.5 M carboxyfluorescein diacetate, succinimidyl ester, (CFDA-SE, Sigma, Milano, Italy) in PBS-G at 0.05% hematocrit

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