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The discovery of the interaction of ATXN3 with the DNA endprocessing enzyme polynucleotide kinase 3-phosphatase (PNKP) renewed the interest on the interplay between protein aggregation and DNA repair

In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

What are the side effects of peptide therapy

Incorporating vitamin B6 can help mitigate side effects such as nausea, stabilize mood, and support energy metabolism, while vitamin B12 is essential for preventing deficiencies, maintaining energy levels, and supporting neurological health