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Its exact mechanism of action is not entirely understood, but it is thought to influence the brains neurotransmitter systems

Mucosal immunity Currently licensed SARS-CoV-2 vaccines are all delivered parenterally via intramuscular injection, which leads to some limitations for vaccine roll-out and potentially for protective efficacy (Table 1)
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CHUMAN, L., FINE, L.G., COHEN, A.H., & SAIER, M.H