glutathione reduction assay principle. Abbreviations: GSH, glutathione; GS-R, Glutathione (GSH & GSSG) Assay
Description
Many of these agents, including peptide-based and hydrophobic small molecules, exhibit poor CNS bioavailability, necessitating advanced delivery systems such as nanoparticles, convection-enhanced delivery, or BBB permeabilizing strategies [113, 153]
Drugs 71 , 13851396 (2011)
ACSL4 plays a dual role in MM: it promotes tumor growth by activating lipid synthesis, but also initiates ferroptosis by catalyzing the production of PUFA-CoA, a key substrate for lipid peroxidation (Zhang et al., 2023)
2019;156:1849.e1813
