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Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]

Nat Rev Urol

In spinal cord injury models, BPC-157 counteracted axonal and neuronal necrosis, demyelination, and cyst formation, with functional improvements maintained for up to 360 days after a single treatment

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