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Elevated oxidative stress and subsequent mitochondrial dysfunction are associated with biological aging

Glucose sensing mediated by portal glucagon-like Peptide 1 receptor is markedly impaired in insulin-resistant obese animals

Transporter-selective pharmacological modulation Growing structural and functional insight into zinc transporters raises the possibility of developing small molecules that selectively modulate individual transporters or their regulators

This concern mainly applies to people taking high doses of biotin, typically in the range of many milligrams per day (far above the normal dietary amount)