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10 M retinoic acid was used as a positive control for maturation towards a differentiated neuronal phenotype, as shown previously ( 2.2 DPI synergizes with MitoQ in MNA NB cells To assess whether MitoQ and DPI act synergistically in reducing cell viability, we treated two MNA NB cell lines (IMR-5/75 and Be(2)-C) with various concentrations of DPI and MitoQ

Call 999 or go to A&E immediately if you experience: Severe difficulty breathing or stridor (a high-pitched sound when breathing) Severe swelling in the throat or neck Drooling or inability to swallow liquids Severe chest pain Contact your GP or NHS 111 if you experience: Severe or worsening throat pain that interferes with swallowing or speaking Difficulty swallowing (dysphagia) , particularly if progressive or associated with pain Persistent symptoms not improving after a week High fever (38C or above) accompanying throat symptoms Visible swelling in the neck or throat Blood in saliva or phlegm Hoarseness lasting more than 3 weeks Severe symptoms of reflux , including persistent heartburn, regurgitation, or chest pain Unintentional weight loss beyond your treatment goals, or inability to maintain adequate nutrition Signs of dehydration , such as reduced urine output, dizziness, or extreme thirst Your GP will conduct a thorough assessment, which may include examination of your throat, neck, and lymph nodes