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The first agent in this class was approved in 2005 for type 2 diabetes, and ongoing studies continue to look at their broader applications, long-term benefits and safety profile

doi: 10.1016/j.mam.2009.01.001

3 The Lancet Phase 1b combination trialEnebo LB et al

Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase