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doi: 10.1038/s41568-022-00459-0

10.1016/j.ccell.2018.03.022 Cancer Cell 44 SakaguchiR.MoriY

the biological complexity and potential for overlapping toxicities when designing combination therapies to exploit synergistic effects across pathways

The rich literature elevating systemic PRL using pituitary isografts in mouse models demonstrates that PRL in combination with progesterone can promote carcinogen- and p53 null-induced tumors [e.g., (6,94)]
