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The analysis underscores that existing research remains largely confined to animal studies, laboratory experiments, and a small number of low-quality human observations, reinforcing the need for cautious interpretation

Following MET activation, transphosphorylation occurs on Tyr 1234 and Tyr 1235 C-terminal region contains two crucial tyrosines (Tyr 1349 and Tyr 1356), which are inserted into the multisubstrate docking site, capable of recruiting downstream adapter proteins with Src homology-2 (SH2) domains

Data from designated brain regions from the cFOS 3D brain imaging study were analysed using one-way ANOVA with Dunnets post hoc multiple-comparison test relative to the vehicle, using a negative binomial generalized linear model to control for Gaussian distribution

Campos BLS, Silva TN, Ribeiro SP, et al