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Aluigi MG, De Flora S, D'Agostini F, Albini A, Fassina G

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

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Each layer provides additional protection, and the multi-layer structure releases glutathione more gradually, creating a sustained-release effect