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As we age, the volume of glutathione maintained in the body reduces dramatically, and can benefit from supplementation

These include hormonal imbalances, nutrient deficiencies, unhealthy dietary habits, lifestyle choices, and environmental exposures

However, research suggests that interventions that target these processes, such as medications that modulate neurotransmitter function or antioxidants that reduce oxidative stress, may be effective in reducing pain and other symptoms in people with FM 14,15,16

This phenomenon, similar to what has been proposed in Parkinsons disease [46], suggests a compensatory mechanism where cells increase transcription to compensate for reduced GPX4 protein levels