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Difficulty initiating and/or maintaining sleep, as well as sleep that is unrefreshing, are key characteristics of insomnia or sleepwake disorder, which frequently co-exists with daytime discomfort or emotional distress

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As a result, the first conclusion we can obtain from these results is that more studies are necessary in order to evaluate potential combinatory treatments in order to delay or prevent AD, which, after all, is a multifactorial disease and might need to be treated through multiple targets