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[Abstract]2024 May 7;15(1):3834

3.5.4 Monocyte chemoattractant protein 1 (MCP-1) Monocyte chemoattractant protein 1 is a chemokine that promotes the recruitment of monocytes and the spread of inflammation

Sustained microglial activation leads to the release of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which exacerbate neuronal injury and amplify amyloid and tau pathology (Kaur et al., 2019)

Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases