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Despite the claim that the Sampson equation is valid up to 9.03 mmol/L (800 mg/dL), LDL-C concentrations were not calculated for subjects with triglyceride concentrations greater than 4.52 mmol/L (400 mg/dL) because the Friedewald and Martin-Hopkins equations are specifically validated for triglyceride concentrations below 4.52 mmol/L ( 6 , 11 )

10.1016/j.ymthe.2021.09.015 Mol Ther

Moreover, the authors found that the levels of inflammatory markers TNF-, interleukin 6 (IL-6), and matrix metallo-proteinase 9 (MMP-9) were significantly decreased in the CoQ 10 -treated group, while the supplementation did not affect the levels of the anti-inflammatory markers interleukin 4 (IL-4) and tissue growth factor (TGF-), hypothesizing that at the basis of these beneficial effects there are antioxidant and anti-inflammatory activities [89]

Feldman, D