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Miettinen showed that in the Scandinavian Simvastatin Survival Study (4S), a high-risk secondary prevention trial of statin-/placebo-treated patients with high LDL-C, hypoabsorbers did and hyperabsorbers did not have a beneficial effect of simvastatin, theoretically because hyperabsorbers are typically hyposynthesizers of cholesterol and therefore less likely to be responsive to a statin [85]

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Rahbar S, Figarola JL (2002) Inhibitors and breakers of advanced glycation endproducts (AGEs): a review