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Patients with hepatopulmonary syndrome often have digital clubbing (see Chapter 92)

Prior to measurement, 2 10 5 PMs were seeded into a Seahorse XF-24 plate (Seahorse Bioscience, #100777-004)

Journal of Nuclear Medicine, 53 (1), 98105

Thus, in DEP patients there could be a decrease of TRP due to abnormal HPA axis functions and metabolic hormone signaling, inducing TDO activity to compete for TPH and 5-HT biosynthesis, without fully recovering this amino acid in plasma
