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Description
Soroceanu L, Gillespie Y, Khazaeli M, Sontheimer H

106 In line with these observations, both IDH1- and IDH2-mutant AML cells were found to be more sensitive to BCL-2 targeting than were the non IDH-mutant AML cells upon treatment with the small molecule inhibitor ABT-199

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Based on the conservative sequence of Nrf2, Nrf2 can be divided into six structural-functional domains, named Neh1-Neh6 ( Figure 1 Kelch-like ECH-related protein-1 (Keap1) is a specific receptor for Nrf2 and the first major inhibitor of Nrf2, mainly present in the cytoplasm
