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The goal of this paper is to review the preclinical and clinical trial evidence published from 2000 to 2020 to assess watermelon intake and l-citrulline, as a signature compound of watermelon, on cardiovascular and metabolic outcomes, and to identify future directions important for establishing dietary guidance and therapeutic recommendations actionable by health care professionals, patients, and the general public

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Loomis et al., 2014), this data could nicely explain the enhanced expression of pre-mutation alleles observed in FXTAS, but experimental evidence is missing